Archive for DNA

Relatives – 19 Names From GEDmatch

Apparently, when two individuals have shared matches of a single DNA strand greater than 10 Centimorgans in length, they are definitely related, probably in the 3rd-5th cousin range.

If any of them come to this site, I would appreciate them (you) sending me an email at ian@marrette.cc .

GEDmatch has found a few for us. FYI, their GEDmatch names are:

Anthony Bates (16.6 cM)
Lee 13.9 cM

Fedor Karpelevitch
ken levine
Alexandr Ivashchenko
Orderedchaos
Yuliya Ivashchenko
Mizya Blyakher
Richard Hawk

Jan Greenspan
CarlMGB
*MSellers
Dane Elliott

Elizabeth Bakwin
Ilya Shlyakhter
Donovan1
Robert Lefkowitz
Naomi Torpey
SpeaksCohn

There are a whole whack more between 5 and 10 cMs, that are considered possible relatives.

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Geographical Connections Through GEDmatch Admixture Analysis

Updated September 18, 2011

Today GEDmatch added a new utility for analysing individuals complete DNA file and coming up with an admixture breakdown by geographical region. I had the utility analyse my data and it produced the columns below.

I wondered what it might say about Frank so I decided to subtract my known western European DNA (mother=50%; paternal grandmother=25%) from the western European total and distribute the difference proportionally across the rest of the percentages. I also decided to try it with taking out 100% of western European DNA to simulate 100% of it coming from the two women. However, it is worth noting the discrepancy between the 75% of DNA contributed by those 3 grandparents is far larger than the 44.9% Western Europe DNA turned up in the analysis. Since we don’t have either DNA analysis or genealogical information on them to use to make a decision about further data extractions, I just left that 30% in.

This discrepancy raises a question however. Theoretically, the total western European DNA credited to Molly and Dory should total almost exactly 75%. However, the analysis only shows 44.9%. What happened to that other 30%? The only explanation that I can think of is that either Molly or Dory or both had some DNA from non-Western European sources. That would be news to me. However, Brian suddenly remembered a conversation with Dory in which she mentioned that her father had mentioned the possibility of some Moroccan ancestry! We have not had time to talk abut that further. In the meantime I am trying to contact Dory’s cousin Tony in Oakville to see if he knows anything or knows if any family members have had DNA testing done. Also, I’m going to contact Bryce, Jeannine and Dennis Sharpe to see if they can shed any light on an Italian connection to the family that his mother, Molly’s half-sister may have mentioned. There was something about a ship building, which was her father’s business.

The distribution over the regions is interesting on its own. However, the adjustment to the western Europe DNA produces fascinating results. After extracting Western Europe, in a gross consolidation the Mediterranean and the West Asian (Arabian Peninsula) added together to total 55%. If you also add SouthWest Asia that total climbs to 62%. Eastern Europe is 30%. The residual 8% is Asian or African.

West Asia includes Saudi Arabia, Israel, Jordan, Lebanon, Syria, Iraq, part of Iran and Turkey as well as smaller countries.

If you want a visual definition of West Asia and the other Asian sectors see the colour map at http://en.wikipedia.org/wiki/Geography_of_Asia

For the time being, we don’t have an explanation for the Eastern European contribution, but it % size would suggest that it is a relatively recent contribution. The original 29.6% would suggest that either of Frank’s parents could have made that contribution but it is unlikely that that great-grandparent would have 100% Eastern European DNA.

GEDmatch Admixture Analysis of Ian McCallum
9/3/2011
**Adjustment by Subtracting Obvious Western European DNA
Mother DNA % 50%
Grandmother DNA % 25%

Removing 100% of Western Europe
New Weighting
Population Self Added
East_European 29.6%
West_European (removed 44.9%)
Mediterranean 44%
Neo_African 0.2%
West_Asian 11.3%
South_Asian 2.3%
Northeast_Asian 1.0%
Southeast_Asian 0.7%
East_African 0.5%
Southwest_Asian 6.7%
Northwest_African 3.5%
Palaeo_African 0.4%
100%

Adjusted Summaries
East_European 30%
Mediterranean+West Asian (Arabian Penninsula – Lebanon, Israel, Jordan, Syria, Iraq, Saudi, Yemen etc) 55%

Note: also read the 23andMe Ancestry Lab posting under Category DNA or Semitics. It is a breakdown of the DNA that is shared with Ashkenazim.

Ian

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By the Numbers – Potential Living Relatives

Living descendants of Frank and his alleged brother, allegedly named John, would number approximately 100, of which the John side might account for about 50. The probability of them having their DNA analyzed by now is probably statistically higher than the population as a whole assuming that they are as curious about their ancestry as some of us are. That probability will increase exponentially as the population as a whole has their DNA analyzed for the health benefits. I haven’t seen any projections, but at the current rate of growth and laboratory discoveries concerning both analysis and targeted gene treatment of illnesses, I wouldn’t be surprised if in 10 years 50% of the population has had their DNA analyzed.

If we look to living descendants of Frank’s grandparents, on both his father’s and mother’s side, then the living relatives could number about 2,500. Some of these would be 5th and 6th cousins. In the DNA research to date, 6th, 5th, 4th and even a couple of 3rd cousin potential relatives have shown up but are yet to be confirmed.

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Explanation of Range of Genetic Analysis for Genealogical Purposes

The site (www.johnbrobb.com/JBRdna.htm) provides a helpful explanation of the range of genetic analysis used for genealogical purposes. Although it could be briefer, it is in reasonably plain English for the layman.

What I would love to find is a table of dilution by generation for the various factors such as SNPs, STRs, genetic distance (CMs), gene segments etc.

Some of the services including 23andMe and GEDmatch provide data and conclusions but then allow you to infer how they used the one to get the other. As a rule of thumb, it appears that the dilution factor is a ratio of 3:1 for each succeeding generation. You have half your father’s DNA and your child will have 1/4 of your father’s DNA. Also, you have 1/4 of your grandfather’s DNA, as does your cousin, but your cousin will not necessarily inherit the same DNA from your grandfather that you did. However, if you and your cousin are both male and are the children of brothers, then you will both have the same Y-chromosome as do your father, uncle and your grandfather.

The calculation of daughters and X-chromosome and mitochondrial DNA is a different calculus altogether.

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Interesting POSSIBLE links to E1b1b1 (M35) Borgheses, Einstein, Wright Brothers and Barrack Obama

Just to show you that you never know who you are going to turn up in your ancestral closet. I haven’t fully verified these claims but they look legit and you can check them for yourselves at the sites listed below. Also, remember that we are 3 mutations farther branched from that haplotype. You may take awhile to get your head around that one.

http://www.borghesegardens.com/borghese_family_tree.htm
http://www.familytreedna.com/cj.aspx?ftdna_ref=500

Feb 18, 2011 : Ancient, Southern Italian Borghese Family Y-DNA (not Roman) Haplogroup E1b1b1 (M35) Y-chromosome DNA Testing
National Geographic Genographic Project Y-DNA Test results:

The designations for all 12 loci examined for this purpose are listed here, along with the Short Tandem Repeats (STRs) outcome for each.

393 390 19 391 385a 385b 426 388 439 389-1 392 389-2

13 24 13 10 16 – 18 11 12 12 14 11 31
Feb 17, 2011 : Out of Africa or the Middle East ?

E1b1b1-M35 DNA of Albert Einstein and Barack Obama. 12% of Spanish Jews are E1b1b, 20% of Eastern European Jews (the ones who migrated east after they moved northward through Italy) are also E1b1b. Albert Einstein was from the 20% of Eastern European Jews and belongs to Haplogroup E1b1b

Barack Obama’s dad is a Luo-Nilotic from East Africa / Kenya.
http://en.wikipedia.org/wiki/Barack_Obama,_Sr.
Feb 16, 2011 : E1b1b1-M35 The Wright Brothers Y-DNA

The Wright Brothers of the United States belonged to Y-DNA haplogroup E1b1b1, subclade E1b1b1a2 (V13). They were supposedly descended from Robert Wright of Brook Hall, Essex, England. Look at Wright DNA Project

DYS – 393-390-19-391-385A-385B-426-388-439-389I-392-389II
Alleles 13 – 24 -13 -10 – 16 – 18 – 11 -12 – 12 – 13 – 11 – 29

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2,191 Potential Relatives and Counting

February 10, 2011 was a major milestone in our search for living relatives, ancestors and our true paternal name.

I was able to compare my genes with 560,000 others via GEDcom yielding 1,200 possible relatives. Via 23andMe we have 991 possible relatives. There is only one named McCallum – Virginia.

We started this blog only in mid-2010 with no expectations of such a major development. Six months later we are beginning to contact the most promising of these and, from there, organizing the family histories and genetic family trees together in an increasingly meaningful way. The exponential growth in people having their DNA analysed will yield increasing potential and relevancy in the months and years to come. It is a big job but the data is growing and tools more powerful and, as a result of my DNA analysis, I have been told by those who read my genes that I have a superior chance of living to be 100, therefore I have many more years to be able to do the work!

This morning, as Egypt’s President Hosni Mubarak resigned, I had a reply from the first and the genetically closest person from that group, someone who appears to be perhaps 6 orders away; not exactly close, but promising. It is safe to say that we will never get completely caught up with family gossip. We’ve not yet spoken but her email was very warm and welcoming.

We still have the documentation search to keep up but these developments are a huge boost to our efforts.

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GEDcom Has Identified 1,200 Potential Relatives

I have just uploaded my file to GEDmatch.com and the huge number of names it now provides as potential matches. I played hookie today to get this far. But the huge learning curve this data provides tells me that I need to dedicate some time to it to get anywhere meaningful.

I started using the Triangulation Tool but there are 1,200 possible relatives from 3rd cousins to those further removed. A third cousin, if I have it right, would mean that our common ancestor was our common great-great-grandfather or mother, that is, Frank’s grandfather or grandmother.

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Basics

If you are on GEDmatch you can find me at M144207 *MccIan.

23andMe is providing some potential 3rd & 4th cousins with whom I’m following up.

Ian

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Relative Finder – DNA Comparison to Find Relatives & Ancestors via Triangulation

A useful service has recently come to my attention via 23AndMe. It enables anyone to run their raw DNA analysis in comparison with others who have also used it and who are out there waiting to be found. When my DNA analysis comes back from 23AndMe in a few weeks, I will run my data as a trial.

E1b1b1c1a M84 has good news/bad news aspects. Since there are relatively so few carrying that Y-chromosome it may take some considerable time before enough of us opt to be tested and then make data available for such triangulation. The good news is that we should be able to plot probable migration more and more precisely as others of our ilk add themselves.

The GEDmatch.Com site provides tools for making ‘deep’ comparisons between genealogies and DNA test results to help identify possible hidden ancestral connections with distant cousins. This is particularly useful when your GEDCOM or list of DNA matches contains hundreds, or even thousands of individuals. This service is provided free to anybody.

Also, you will find instructions for 23AndMe on that site.

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E1b1b1 haplogroup is second most prevalent haplogroup among the Jewish population

Y-chromosomal Aaron

From Wikipedia, the free encyclopedia

Y-chromosomal Levi (para)

The E1b1b1 haplogroup (formerly known as E3b1) has been observed in all Jewish groups worldwide. It is considered to be the second most prevalent haplogroup among the Jewish population outside of the J haplogroups. According to one non-peer reviewed paper[46] it has also been observed in moderate numbers among individuals from Ashkenazi, Sephardic and Samaritan communities having traditions of descending from the tribe of Levi, suggesting that the E1b1b1 men claiming to be Levites may have existed in Israel before the Diaspora of 70 C.E.

http://en.wikipedia.org/wiki/Y-chromosomal_Aaron

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